In the phase III RISE UP trial, mitapivat improved hemoglobin response but did not significantly reduce sickle cell pain crises versus placebo.
Late-Stage Sickle Cell Disease Study Splits On Main Goals
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Menopause Can Affect Your Heart Health—here Are Three Symptoms A Cardiologist Says Women Should Never Ignore
A cardiologist says new chest discomfort, unusual breathlessness and persistent palpitations during menopause warrant attention and, in some cases, urgent care.
Scientists Discover A Hidden Driver Of High Cholesterol And A Way To Stop It
A UC San Diego study links Ral and CTSA to reduced liver LDL receptors in experiments, and identifies a previously safety-tested drug candidate.
As Measles Outbreak Hits Pennsylvania Amish Country, More Show Openness To Vaccines
As Pennsylvania reports more than 1,350 measles cases this year, some Amish and Mennonite residents are becoming more open to vaccination.
A New Framework For Safe, Patient-centered Prescribing Of Obesity Medications In Older Adults
The American Geriatrics Society’s new framework outlines assessments and supportive care for prescribing obesity medications to older adults.
Screened For Diabetes At 23 BMI, Denied GLP-1s Until 30 BMI
A physician says diabetes screening begins at BMI 23 for Asian patients, while GLP-1 coverage rules may still require BMI 30 or 27 with a related condition.
CDC Says These Superbugs Kill 50,000 Americans Per Year
The CDC estimates pathogens on its 2026 antimicrobial-resistance list cause 9.7 million U.S. infections and 50,800 deaths annually.
SNN Dealbook: New Nursing Home Builds Gain Traction In Kentucky, West Virginia
Signature HealthCARE and the University of Kentucky plan 105 beds; Majestic Care is investing $50 million in three West Virginia nursing homes.
A Health Update
Craig Hockenberry describes chemotherapy, complications and gradual recovery in an Oct. 28 health update; his longer-term outlook remains unclear.
AI May Help Detect Rare Sperm In Men With Azoospermia
At an ASRM meeting, researchers reported that STAR found sperm in some samples previously read as sperm-negative, with three live births reported so far.
